Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …

DNA and RNA play pivotal roles in life processes by storing and transferring genetic
information, modulating gene expression, and contributing to essential cellular machinery …

Determining the RNA binding preferences remains challenging because of the bottleneck of
the binding interactions accompanied by subtle RNA flexibility. Typically, designing RNA …

In this review, we retraced the '40-year evolution'of molecular docking algorithms. Over the
course of the years, their development allowed to progress from the so-called 'rigid …

RNA molecules can act as potential drug targets in different diseases, as their dysregulated
expression or misfolding can alter various cellular processes. Noncoding RNAs account …

Fluorescence indicators capable of binding to human immunodeficiency virus-1 (HIV-1)
trans-activation responsive (TAR) RNA are powerful tools for the exploratory studies of the …

Small molecules and short peptides that potently and selectively bind RNA are rare, making
the molecular structures of these complexes highly exceptional. Accordingly, several recent …

In the TAR RNA of immunodeficiency viruses, an allosteric communication exists between a
distant loop and a bulge. The bulge interacts with the TAT protein vital for transactivating …