There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …

Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of
doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant …

Fatty acids are a major fuel source used to sustain contractile function in heart and oxidative
skeletal muscle. To meet the energy demands of these muscles, the uptake and β-oxidation …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Rationale: Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator–
activated receptor (PPAR) α and under normal conditions accounts for 70% of cardiac ATP …

Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …

Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as
coronary artery disease and hypertension. Diminished glucose uptake due to impaired …

Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart
failure. Multiple structural and biochemical reasons have been suggested to induce this …

Protein phosphorylation is involved in nearly all essential biochemical pathways and the
deregulation of phosphorylation events has been associated with the onset of numerous …