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Myocardial fatty acid metabolism in health and disease
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
Endothelial cell–cardiomyocyte crosstalk in heart development and disease
The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …
normal cardiac development, but also a key pathogenic player during the onset and …
[HTML][HTML] Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway
C Hu, X Zhang, W Wei, N Zhang, H Wu, Z Ma… - … Pharmaceutica Sinica B, 2019 - Elsevier
Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of
doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant …
doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant …
Role of fatty acid uptake and fatty acid β-oxidation in mediating insulin resistance in heart and skeletal muscle
Fatty acids are a major fuel source used to sustain contractile function in heart and oxidative
skeletal muscle. To meet the energy demands of these muscles, the uptake and β-oxidation …
skeletal muscle. To meet the energy demands of these muscles, the uptake and β-oxidation …
Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy
A Wan, B Rodrigues - Cardiovascular research, 2016 - academic.oup.com
The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …
Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function
Rationale: Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator–
activated receptor (PPAR) α and under normal conditions accounts for 70% of cardiac ATP …
activated receptor (PPAR) α and under normal conditions accounts for 70% of cardiac ATP …
[HTML][HTML] Molecular mechanisms of cardiac pathology in diabetes–Experimental insights
Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as
coronary artery disease and hypertension. Diminished glucose uptake due to impaired …
coronary artery disease and hypertension. Diminished glucose uptake due to impaired …
FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival
Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart
failure. Multiple structural and biochemical reasons have been suggested to induce this …
failure. Multiple structural and biochemical reasons have been suggested to induce this …
Lipoprotein lipase as a target for obesity/diabetes related cardiovascular disease
R Shang, B Rodrigues - Journal of Pharmacy & …, 2024 - frontierspartnerships.org
Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …
their leading cause of death. Traditionally, the management of obesity and diabetes has …
Tandem mass spectrometry strategies for phosphoproteome analysis
Protein phosphorylation is involved in nearly all essential biochemical pathways and the
deregulation of phosphorylation events has been associated with the onset of numerous …
deregulation of phosphorylation events has been associated with the onset of numerous …