Recent developments in bioprocessing of recombinant proteins: expression hosts and process development
NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …
humans worldwide. The production of therapeutic proteins for treating diseases at large …
Trends in upstream and downstream process development for antibody manufacturing
P Gronemeyer, R Ditz, J Strube - Bioengineering, 2014 - mdpi.com
A steady increase of product titers and the corresponding change in impurity composition
represent a challenge for development and optimization of antibody production processes …
represent a challenge for development and optimization of antibody production processes …
Recent advances in large-scale production of monoclonal antibodies and related proteins
AA Shukla, J Thömmes - Trends in biotechnology, 2010 - cell.com
The rapid development of high-yielding and robust manufacturing processes for monoclonal
antibodies is an area of significant focus in the biopharmaceutical landscape. Advances in …
antibodies is an area of significant focus in the biopharmaceutical landscape. Advances in …
Advances in the production and downstream processing of antibodies
JH Chon, G Zarbis-Papastoitsis - New biotechnology, 2011 - Elsevier
Sales of monoclonal antibody (mAbs) therapies exceeded
40billionin2010andareexpectedtoreach 70 billion by 2015. The majority of the approved …
40billionin2010andareexpectedtoreach 70 billion by 2015. The majority of the approved …
Guidelines to cell engineering for monoclonal antibody production
Monoclonal antibodies (mAbs) are currently used for many diagnostic and therapeutic
applications. The high demand for these biopharmaceuticals has led to the development of …
applications. The high demand for these biopharmaceuticals has led to the development of …
Economic analysis of batch and continuous biopharmaceutical antibody production: A review
Purpose There is a growing interest in continuous biopharmaceutical processing due to the
advantages of small footprint, increased productivity, consistent product quality, high …
advantages of small footprint, increased productivity, consistent product quality, high …
Accelerating biologics manufacturing by modeling or: is approval under the QbD and PAT approaches demanded by authorities acceptable without a digital-twin?
S Zobel-Roos, A Schmidt, F Mestmäcker, M Mouellef… - Processes, 2019 - mdpi.com
Innovative biologics, including cell therapeutics, virus-like particles, exosomes, recombinant
proteins, and peptides, seem likely to substitute monoclonal antibodies as the main …
proteins, and peptides, seem likely to substitute monoclonal antibodies as the main …
Microfluidic cell retention device for perfusion of mammalian suspension culture
T Kwon, H Prentice, JD Oliveira, N Madziva… - Scientific reports, 2017 - nature.com
Continuous production of biologics, a growing trend in the biopharmaceutical industry,
requires a reliable and efficient cell retention device that also maintains cell viability. Current …
requires a reliable and efficient cell retention device that also maintains cell viability. Current …
Technological progresses in monoclonal antibody production systems
Monoclonal antibodies (mAbs) have become vitally important to modern medicine and are
currently one of the major biopharmaceutical products in development. However, the high …
currently one of the major biopharmaceutical products in development. However, the high …
Process analytical technology as key‐enabler for digital twins in continuous biomanufacturing
A Schmidt, H Helgers, LJ Lohmann… - Journal of Chemical …, 2022 - Wiley Online Library
Over the last few years rapid progress has been made in adopting well‐known process
modeling techniques from chemicals to biologics manufacturing. The main challenge has …
modeling techniques from chemicals to biologics manufacturing. The main challenge has …