Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that
has been implicated in the pathogenesis of several postoperative complications. Recent …

THE purpose of this review is to evaluate recent developments in our understanding of the
inflammatory response to cardiac surgery. Scientific knowledge in this field is continually …

Background Recent study of the inflammatory reactions occurring during and after
cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the …

BACKGROUND: One of the novel and promising plasma markers for detection of tissue
injury is the family of 15 kDa cytoplasmic fatty acid-binding proteins of which various tissue …

Address reprint requests to Oliver J. Warren, MRCS (Eng), Department of BioSurgery and
Surgical Technology, Imperial College London, 10th Floor QEQM Building, St Mary's …

Background There is no therapy known to reduce the risk of complications or death after
coronary bypass surgery. Because platelet activation constitutes a pivotal mechanism for …

As an assay for endotoxin, the Limulus amebocyte lysate assay has several desirable
properties: sensitivity, specificity, and potential for adaptation to a quantitative format …

OBJECTIVES: Intestinal-type fatty acid-binding protein (I-FABP) has been proposed as
plasma marker for the detection of acute intestinal injury. However, intestinal mucosa also …

Cardiopulmonary bypass is often followed by pulmonary dysfunction as assessed by
measuring the alveolar-arterial oxygenation gradient, intrapulmonary shunt, degree of …

C ardiac surgery and cardiopulmonary bypass (CPB) activate a systemic inflammatory
response characterized clinically by alterations in cardiovascular and pulmonary function …