Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and
progression of Parkinson's disease (PD). Glutathione (GSH) and the reduced/oxidized …

The role of glutathione in autism spectrum disorder (ASD) is emerging as a major topic, due
to its role in the maintenance of the intracellular redox balance. Several studies have …

Extracellular signal‐regulated kinase (ERK) is a versatile protein kinase that regulates many
cellular functions. Growing evidence suggests that ERK1/2 plays a crucial role in promoting …

The pathogenesis of several neuropsychiatric disorders, including anxiety and depression,
has been linked to oxidative stress, in part via alterations in cyclic nucleotide signaling …

Glutamate toxicity involves increases in intracellular calcium levels and enhanced formation
of reactive oxygen species (ROS) causing neuronal dysfunction and death in acute and …

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic nigrostriatal
neurons, which leads to disabling motor disturbances. Sulforaphane (SFN), found in …

Ferroptosis is a caspase-independent, iron-dependent form of regulated necrosis extant in
traumatic brain injury, Huntington disease, and hemorrhagic stroke. It can be activated by …

The role of glia in Parkinson's disease (PD) is very interesting because it may open new
therapeutic strategies in this disease. Traditionally it has been considered that astrocytes …

Background Resveratrol exhibits beneficial effects against numerous degenerative diseases
at different stages of pathogenesis. This study investigated potential mechanisms and …

Parkin mutations in humans produce parkinsonism whose pathogenesis is related to
impaired protein degradation, increased free radicals, and abnormal neurotransmitter …