The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …

As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …

Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms
underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show …

Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor
microenvironment and are generally considered to be antitumorigenic. Using single-cell …

The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …

Although emerging cell-or animal-based evidence supports the relationship between SND1
and cancers, no pan-cancer analysis is available. We thus first explored the potential …

Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease.
Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying …

Triple-negative breast cancer (TNBC) patients have the worst prognosis and distant
metastasis-free survival among all major subtypes of breast cancer. The poor clinical outlook …

With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome
therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at …