Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Biomolecular condensates assemble in living cells through phase separation and related
phase transitions. An underappreciated feature of these dynamic molecular assemblies is …

Biomolecular condensates are thought to create subcellular microenvironments that
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …

Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles
within cells, with implications in various biological processes and disease states. AT-rich …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …

Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

Phase separation and percolation contribute to phase transitions of multivalent
macromolecules. Contributions of percolation are evident through the viscoelasticity of …

Foundational models of transcriptional regulation involve the assembly of protein complexes
at DNA elements associated with specific genes. These assemblies, which can include …