Major depression is one of the leading causes of disability, morbidity, and mortality
worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the …

The alterations of functional connectivity brain networks in major depressive disorder (MDD)
have been subject of a large number of studies. Using different methodologies and focusing …

Increasing numbers of studies have suggested that the gut microbiota is involved in the
pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive …

Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …

Background Depression is associated with problems in social functioning. Impaired
empathic abilities might underlie this association. Empathy is a multidimensional construct …

The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

Depression has been widely accepted as a major psychiatric disease affecting nearly 350
million people worldwide. Research focus is now shifting from studying the extrinsic and …

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused global
disruptions with serious psychological impacts. This study investigated the emergence of …

Background: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired
white matter integrity in patients with major depressive disorder (MDD), with significant …

Despite decades of research on the neurobiology of major depressive disorder (MDD), the
mechanisms underlying its expression remain unknown. The medial prefrontal cortex …