Chondral and osteochondral lesions due to injury or other pathology commonly result in the
development of osteoarthritis, eventually leading to progressive total joint destruction …

One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Context: Isolated chondral and osteochondral defects of the knee are a difficult clinical
challenge, particularly in younger patients for whom alternatives such as partial or total knee …

Background: The surfaces of the bones in the knee are covered with articular cartilage, a
rubber-like substance that is very smooth, allowing frictionless movement in the joint and …

Background: The management of cartilage and osteochondral lesions in the knee remains
problematic and controversial. Our group reported the 2-year and 5-year results of a …

Purpose Optimal surgical treatment of chondral defects in an athletic population remains
highly controversial and has yet to be determined. The purpose of this review was to (1) …

Objective To create a treatment algorithm for focal grade 3 or 4 cartilage defects of the knee
using both classic and novel cartilage restoration techniques. Design A comprehensive …

Background Autologous chondrocyte implantation (ACI) is an established and well-accepted
procedure for the treatment of localised full-thickness cartilage defects of the knee. Methods …

There is currently widespread interest within the biomaterial field to locally deliver
biomolecules for bone and cartilage regeneration. Substantial work to date has focused on …

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