ReMAP** the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins

A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Tuft cells—systemically dispersed sensory epithelia integrating immune and neural circuitry

CE O'Leary, C Schneider… - Annual review of …, 2019 - annualreviews.org
Tuft cells—rare solitary chemosensory cells in mucosal epithelia—are undergoing intense
scientific scrutiny fueled by recent discovery of unsuspected connections to type 2 immunity …

A combinatorial MAP code dictates polarized microtubule transport

BY Monroy, TC Tan, JM Oclaman, JS Han, S Simó… - Developmental cell, 2020 - cell.com
Many eukaryotic cells distribute their intracellular components asymmetrically through
regulated active transport driven by molecular motors along microtubule tracks. While …

Discovery of a selective inhibitor of doublecortin like kinase 1

FM Ferguson, B Nabet, S Raghavan, Y Liu… - Nature chemical …, 2020 - nature.com
Abstract Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in
a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However …

[HTML][HTML] DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis

JH Kim, SY Park, SE Jeon, JH Choi, CJ Lee… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that
selectively marks cancer stem-like cells (CSCs) and promotes malignant progression in …

Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer

S Dogra, SP Elayapillai, D Qu, K Pitts, A Filatenkov… - Cancer Letters, 2023 - Elsevier
Ovarian cancer (OvCa) has a dismal prognosis because of its late-stage diagnosis and the
emergence of chemoresistance. Doublecortin-like kinase 1 (DCLK1) is a serine/threonine …

Pleiotropic effects of DCLK1 in cancer and cancer stem cells

D Chhetri, S Vengadassalapathy… - Frontiers in Molecular …, 2022 - frontiersin.org
Doublecortin-like kinase 1 (DCLK1), a protein molecule, has been identified as a tumor stem
cell marker in the cancer cells of gastrointestinal, pancreas, and human colon. DCLK1 …

Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ

W Luo, Y **, Y Jiang, L Yang, H Xu, D Wu… - Cell Death & …, 2023 - nature.com
Abstract Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is
involved in neurogenesis, and its levels are elevated in various human cancers. Recent …

Chemical probes for understudied kinases: challenges and opportunities

RAM Serafim, JM Elkins, WJ Zuercher… - Journal of Medicinal …, 2021 - ACS Publications
Over 20 years after the approval of the first-in-class protein kinase inhibitor imatinib, the
biological function of a significant fraction of the human kinome remains poorly understood …

Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

FS Yuliani, JY Chen, WH Cheng, HC Wen… - Journal of Biomedical …, 2022 - Springer
Background Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer
stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL …