Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
[HTML][HTML] 3D in vitro model (R) evolution: unveiling tumor–stroma interactions
The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …
progression. The physical and biochemical characteristics of this niche are involved in …
Decellularization in tissue engineering and regenerative medicine: evaluation, modification, and application methods
Reproduction of different tissues using scaffolds and materials is a major element in
regenerative medicine. The regeneration of whole organs with decellularized extracellular …
regenerative medicine. The regeneration of whole organs with decellularized extracellular …
Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine
S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
[HTML][HTML] Mechanical regulation of transcription: recent advances
Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
[HTML][HTML] Research progress in decellularized extracellular matrix-derived hydrogels
W Zhang, A Du, S Liu, M Lv, S Chen - Regenerative therapy, 2021 - Elsevier
Decellularized extracellular matrix (dECM) is widely used in regenerative medicine as a
scaffold material due to its unique biological activity and good biocompatibility. Hydrogel is a …
scaffold material due to its unique biological activity and good biocompatibility. Hydrogel is a …
Current advances in 3D bioprinting for cancer modeling and personalized medicine
N Germain, M Dhayer, S Dekiouk… - International journal of …, 2022 - mdpi.com
Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …
Fabrication and characterization of PCL/HA filament as a 3D printing material using thermal extrusion technology for bone tissue engineering
The most common three-dimensional (3D) printing method is material extrusion, where a pre-
made filament is deposited layer-by-layer. In recent years, low-cost polycaprolactone (PCL) …
made filament is deposited layer-by-layer. In recent years, low-cost polycaprolactone (PCL) …
Bioprinting decellularized breast tissue for the development of three-dimensional breast cancer models
B Blanco-Fernandez, S Rey-Vinolas… - … applied materials & …, 2022 - ACS Publications
The tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug
resistance. Previous studies have shown that breast tissue-derived matrices could be an …
resistance. Previous studies have shown that breast tissue-derived matrices could be an …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …