PfEMP1 and var genes-Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
L Hviid, AR Jensen, KW Deitsch - Advances in …, 2024 - pubmed.ncbi.nlm.nih.gov
The most severe form of malaria, caused by infection with Plasmodium falciparum parasites,
continues to be an important cause of human suffering and poverty. The P. falciparum …
continues to be an important cause of human suffering and poverty. The P. falciparum …
Broadly inhibitory antibodies to severe malaria virulence proteins
Malaria pathology is driven by the accumulation of Plasmodium falciparum-infected
erythrocytes in microvessels. This process is mediated by the polymorphic erythrocyte …
erythrocytes in microvessels. This process is mediated by the polymorphic erythrocyte …
Malaria monoclonals block brain binding
In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs,
including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected …
including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected …
[HTML][HTML] Broadly inhibitory antibodies against severe malaria virulence proteins
Plasmodium falciparum pathology is driven by the accumulation of parasite-infected
erythrocytes in microvessels. This process is mediated by the parasite's polymorphic …
erythrocytes in microvessels. This process is mediated by the parasite's polymorphic …
A system for functional studies of the major virulence factor of malaria parasites
J Cronshagen, J Allweier, P Mesén-Ramírez, J Stäcker… - bioRxiv, 2024 - biorxiv.org
PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite
Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of …
Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of …
Plasma from older children in Malawi inhibits Plasmodium falciparum binding in 3D brain microvessels
F Joof, R Hu, A Saidi, KB Seydel… - The Journal of …, 2024 - academic.oup.com
A hallmark of cerebral malaria is sequestration of Plasmodium falciparum-infected
erythrocytes (IEs) in the brain microcirculation. Antibodies contribute to malaria immunity, but …
erythrocytes (IEs) in the brain microcirculation. Antibodies contribute to malaria immunity, but …
Diverse and weakly immunogenic var gene expression facilitates malaria infection
Plasmodium falciparum is believed to escape immunity via antigenic variation, mediated in
part by 60 var genes. These genes undergo mutually exclusive expression and encode the …
part by 60 var genes. These genes undergo mutually exclusive expression and encode the …
Host receptor binding induces conformational changes in a PfEMP1 protein
In this issue of Structure, Raghavan et al. present the cryo-EM structures of the malaria-
associated group A PfEMP1 HB3VAR03 head in both host receptor-free and receptor-bound …
associated group A PfEMP1 HB3VAR03 head in both host receptor-free and receptor-bound …