Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

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The presence of somatic mutations, including copy number variants (CNVs), in the brain is
well recognized. Comprehensive study requires single-cell whole genome amplification …

Abstract Background and Purpose Multiple system atrophy (MSA) is a progressive, adult‐
onset neurodegenerative disorder clinically characterized by combinations of autonomic …

The advent of single cell DNA sequencing revealed astonishing dynamics of genomic
variability, but failed at characterizing smaller to mid size variants that on the germline level …

Background Idiopathic Late-Onset Cerebellar Ataxia (ILOCA) is a challenging and
heterogeneous disorder characterized by progressive cerebellar ataxia beginning after the …

Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with
a substantial genetic background. However, its underlying genetic architecture remains to …

Multiple system atrophy is an adult-onset, sporadic, and progressive neurodegenerative
disease. People with this disorder report a wide range of motor and non-motor symptoms …

Purpose This study examined occupational histories in multiple system atrophy to identify
environmental associations of potential relevance to disease causation. Methods A total of …

Abstract Background: Alpha-synucleinopathies, including Parkinson's disease (PD), multiple
system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative …