Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Cancer is associated with significant morbimortality globally. Advances in screening,
diagnosis, management and survivorship were substantial in the last decades, however …

Cancer of unknown primary (CUP) origin is an enigmatic group of diagnoses in which the
primary anatomical site of tumour origin cannot be determined,. This poses a considerable …

Background Recently, the US Food and Drug Administration (FDA) has approved immune
checkpoint blockade (ICB) for treating cancer patients with tumor mutation burden (TMB)> …

Cancer of unknown primary (CUP) site poses diagnostic challenges due to its elusive
nature. Many cases of CUP manifest as pleural and peritoneal serous effusions. Leveraging …

Importance Although profiling of gene expression and gene alterations by next-generation
sequencing (NGS) to predict the primary tumor site and guide molecularly targeted therapy …

Aim To determine the differential effect of the treatment periods on the survival of patients
with stage IV serous papillary peritoneal carcinoma (SPPC), fallopian tube cancers, and …

As data-driven science, artificial intelligence (AI) has paved a promising path toward an
evolving health system teeming with thrilling opportunities for precision oncology …

Background Determining the origin of bone metastatic cancer (OBMC) is of great
significance to clinical therapeutics. It is challenging for pathologists to determine the OBMC …

Cancer metastasis and drug resistance are two major obstacles in the treatment of cancer
and therefore, the leading cause of cancer-associated mortalities worldwide. Hence, an in …