Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

The multidimensional mechanisms of long noncoding RNA function

FP Marchese, I Raimondi, M Huarte - Genome biology, 2017 - Springer
A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Z Bao, Z Yang, Z Huang, Y Zhou, Q Cui… - Nucleic acids …, 2019 - academic.oup.com
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is
involved in a wide variety of diseases. A knowledgebase with systematic collection and …

[HTML][HTML] Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D **e, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

NONCODEV5: a comprehensive annotation database for long non-coding RNAs

SS Fang, LL Zhang, JC Guo, YW Niu, Y Wu… - Nucleic acids …, 2018 - academic.oup.com
Abstract NONCODE (http://www. bioinfo. org/noncode/) is a systematic database that is
dedicated to presenting the most complete collection and annotation of non-coding RNAs …

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Q Hu, Y Ye, LC Chan, Y Li, K Liang, A Lin… - Nature …, 2019 - nature.com
How tumor cells genetically lose antigenicity and evade immune checkpoints remains
largely elusive. We report that tissue-specific expression of the human long noncoding RNA …

[HTML][HTML] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

OM de Goede, DC Nachun, NM Ferraro… - Cell, 2021 - cell.com
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still …

Molecular events in neuroendocrine prostate cancer development

Y Wang, Y Wang, X Ci, SYC Choi, F Crea, D Lin… - Nature Reviews …, 2021 - nature.com
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

ncRNA-encoded peptides or proteins and cancer

J Wang, S Zhu, N Meng, Y He, R Lu, GR Yan - Molecular Therapy, 2019 - cell.com
Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in
the eukaryotic genome and have been shown to play key roles in the development of many …