Leishmaniasis is a major public health problem and till date there are no effective vaccines
available. The control strategy relies solely on chemotherapy of the infected people …

Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

Leishmaniasis is a neglected tropical disease with no effective vaccines to date. Globally, it
affects around 14 million people living in undeveloped and develo** countries …

Kinetoplast DNA (kDNA), the mitochondrial DNA of flagellated protozoa of the order
Kinetoplastida, is unique in its structure, function and mode of replication. It consists of few …

The Trypanosomatidae family, composed of unicellular parasites, causes severe vector-
borne diseases that afflict human populations worldwide. Chagas disease, slee** …

Leishmania donovani topoisomerase I is an unusual bi-subunit enzyme. The activity of the
enzyme has been detected when the genes of the individual subunits were co-expressed in …

Abstract The protozoan parasites Trypanosoma, Leishmania and Crithidia, which belong to
the order kinetoplastidae, emerge from the most ancient eukaryotic lineages. The diversity …

Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp
and Trypanosoma cruzi, respectively, are among the most important parasitic diseases …

Different classes of topoisomerase (TOP) inhibitors and antitrypanosomatid agents exhibited
variable efficacies against Leishmania donovani parasites and human mononuclear cells …

African trypanosomes are ancient eukaryotes that cause lethal disease in humans and
cattle. Available drugs are inadequate and the need for new therapeutic targets is great …