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Novel quinazolin-2-yl 1, 2, 3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study
In our study, a series of quinazoline-1, 2, 3-triazole hybrids (14a-r) have been designed and
synthesized as multi-target EGFR, VEGFR-2, and Topo II inhibitors. All synthesized hybrids …
synthesized as multi-target EGFR, VEGFR-2, and Topo II inhibitors. All synthesized hybrids …
Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancer via P53, BAX, caspases-3, 6, 8, 9, BCL-2, MMP2, and MMP9 …
Organoselenium (OSe) agents hold promise for preventing cancer due to their potential
ability to fight cancer development and protect cells from oxidative damage. Herein, OSe …
ability to fight cancer development and protect cells from oxidative damage. Herein, OSe …
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
Pyrimidine-based dual-target inhibitors targeting epidermal growth factor receptor for overcoming drug resistance in cancer therapy (2006-present)
Y An, X Lv, S Xu, H Li, P Zheng, W Zhu… - European Journal of …, 2025 - Elsevier
The epidermal growth factor receptor (EGFR) is a pivotal member of the epidermal growth
factor receptor family, exerting crucial regulatory influence on cellular physiological …
factor receptor family, exerting crucial regulatory influence on cellular physiological …
Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and …
A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …
Machine learning-based approach to develo** potent EGFR inhibitors for breast cancer─ design, synthesis, and in vitro evaluation
The epidermal growth factor receptor (EGFR) is vital for regulating cellular functions,
including cell division, migration, survival, apoptosis, angiogenesis, and cancer. EGFR …
including cell division, migration, survival, apoptosis, angiogenesis, and cancer. EGFR …
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4 (5H)-ones as potential apoptotic inducers targeting wild …
A novel series of ethylidenehydrazineylthiazol-4 (5H)-ones were synthesized using various
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl) thio) acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro …
In this work, additional effort was applied to design new BIBR1532-based analogues with
potential inhibitory activity against telomerase and acting as multitarget antitumor candidates …
potential inhibitory activity against telomerase and acting as multitarget antitumor candidates …
Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers
Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
Pharmacophore‐based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA …
A series of tetrahydrobenzo [b] thiophene derivatives was designed and synthesized as dual
topoisomerase (Topo) I/II inhibitors implicating potential DNA intercalation. Ethyl‐2‐amino‐3 …
topoisomerase (Topo) I/II inhibitors implicating potential DNA intercalation. Ethyl‐2‐amino‐3 …