Peripheral apoptosis and limited clonal deletion during physiologic murine B lymphocyte development
MJA Simpson, AM Newen, C McNees… - Nature …, 2024 - nature.com
Self-reactive and polyreactive B cells generated during B cell development are silenced by
either apoptosis, clonal deletion, receptor editing or anergy to avoid autoimmunity. The …
either apoptosis, clonal deletion, receptor editing or anergy to avoid autoimmunity. The …
The sequences encoded by immunoglobulin diversity (DH) gene segments play key roles in controlling B‐cell development, antigen‐binding site diversity, and …
Although at first glance the diversity of the immunoglobulin repertoire appears random, there
are a number of mechanisms that act to constrain diversity. For example, key mechanisms …
are a number of mechanisms that act to constrain diversity. For example, key mechanisms …
Differences in the composition of the human antibody repertoire by B cell subsets in the blood
The vast initial diversity of the antibody repertoire is generated centrally by means of a
complex series of V (D) J gene rearrangement events, variation in the site of gene segment …
complex series of V (D) J gene rearrangement events, variation in the site of gene segment …
Conditional Deletion of Sost in MSC‐Derived Lineages Identifies Specific Cell‐Type Contributions to Bone Mass and B‐Cell Development
Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via
antibodies has shown great therapeutic promise by increasing both bone mass in humans …
antibodies has shown great therapeutic promise by increasing both bone mass in humans …
Massively parallel sequencing of peritoneal and splenic B cell repertoires highlights unique properties of B-1 cell antibodies
B-1 cells are a unique subset of B cells that are positively selected for expressing
autoreactive BCRs. We isolated RNA from peritoneal (B-1a, B-1b, B-2) and splenic (B-1a …
autoreactive BCRs. We isolated RNA from peritoneal (B-1a, B-1b, B-2) and splenic (B-1a …
Immunodominant surface epitopes power immune evasion in the African trypanosome
A Gkeka, F Aresta-Branco, G Triller, EP Vlachou… - Cell Reports, 2023 - cell.com
The African trypanosome survives the immune response of its mammalian host by antigenic
variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we …
variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we …
Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis
H Batoulis, M Wunsch, J Birkenheier, A Rottlaender… - Clinical …, 2015 - Elsevier
In multiple sclerosis (MS) lymphoid follicle-like aggregates have been reported in the
meninges of patients. Here we investigated the functional relevance of B cell infiltration into …
meninges of patients. Here we investigated the functional relevance of B cell infiltration into …
Special AT-rich sequence-binding protein 1 supports survival and maturation of naive B cells stimulated by B cell receptors
T Ozawa, K Fujii, T Sudo, R Nakai… - The Journal of …, 2022 - journals.aai.org
Epigenetic mechanisms underpin the elaborate activities of essential transcription factors in
lymphocyte development. Special AT-rich sequence-binding protein 1 (SATB1) is a …
lymphocyte development. Special AT-rich sequence-binding protein 1 (SATB1) is a …
VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites
Developmental checkpoints eliminate B cells that synthesize defective immunoglobulin (Ig)
heavy (HC) and light (LC) chains. The first checkpoint tests μHCs paired with VpreB/λ5 in a …
heavy (HC) and light (LC) chains. The first checkpoint tests μHCs paired with VpreB/λ5 in a …
Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 …
Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to
block the production of self-reactive antibodies, especially those that bind double-stranded …
block the production of self-reactive antibodies, especially those that bind double-stranded …