Virological failure after switch to long-acting cabotegravir and rilpivirine injectable therapy: an in-depth analysis

BJ van Welzen, SFL Van Lelyveld… - Clinical Infectious …, 2024 - academic.oup.com
Background Long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine
(RPV) is currently used as maintenance treatment for human immunodeficiency virus type 1 …

Therapeutic drug monitoring of antiretroviral therapy: current progresses and future directions

D Cattaneo, C Gervasoni - Expert Review of Clinical Pharmacology, 2024 - Taylor & Francis
Introduction The treatment of HIV infection has been revolutionized in recent years thanks to
the advent of dual antiretroviral regimens, administered orally or as long-acting injectable …

Use of long-acting injectable cabotegravir/rilpivirine in people with HIV and adherence challenges

KA Christopoulos, MD Hickey… - Current Opinion in HIV and …, 2025 - journals.lww.com
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Guidance for the interpretation of long-acting cabotegravir and rilpivirine concentrations based on real-world therapeutic drug monitoring data and documented …

P Thoueille, M Cavassini, M Guidi… - Open forum …, 2024 - academic.oup.com
The interpretation of long-acting cabotegravir and rilpivirine concentrations is complicated
by the lack of consensus on the threshold to consider. Building on real-world therapeutic …

Population Pharmacokinetics of Cabotegravir Following Oral Administration and Long‐Acting Intramuscular Injection in Real‐World People with HIV

P Thoueille, SA Saldanha, F Schaller… - Clinical …, 2024 - Wiley Online Library
Long‐acting cabotegravir has been studied mainly in the stringent framework of clinical
trials, which does not necessarily reflect the situation of people with HIV (PWH) in routine …

Rilpivirine and cabotegravir trough concentrations in people with HIV on long-term treatment with long-acting injectable antiretrovirals

MV Cossu, D Cattaneo, D Moschese… - Journal of …, 2024 - academic.oup.com
Objective Large inter-individual variability in the pharmacokinetics of rilpivirine and
cabotegravir has been reported in the first weeks after starting long-acting injectable (LAI) …

Appropriateness of virological monitoring with long-acting injectable cabotegravir and rilpivirine

D Ripamonti, A Borghetti, M Zazzi - Journal of Antimicrobial …, 2024 - academic.oup.com
Current high-genetic-barrier regimens (either boosted PI-or second-generation integrase
inhibitor-based options), allow long-term control of HIV replication in people living with HIV …

Effectiveness of bi-monthly long-acting injectable cabotegravir and rilpivirine as maintenance treatment for HIV-1 in the Netherlands: results from the Dutch ATHENA …

VW Jongen, FWNM Wit, A Boyd, A van Eeden… - The Lancet …, 2025 - thelancet.com
Background Real-world data showing the long-term effectiveness of long-acting injectable
cabotegravir and rilpivirine are scarce. We assessed the effectiveness of cabotegravir and …

One year of long-acting cabotegravir and rilpivirine in people with human immunodeficiency virus and long exposure to antiretroviral therapy: data from the …

C Muccini, N Gianotti, S Diotallevi… - Open Forum …, 2024 - academic.oup.com
Background The aim of the study was to evaluate the 12-month cumulative probability of
treatment discontinuation (TD) in people with human immunodeficiency virus (HIV; PWH) …