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[HTML][HTML] A framework for studying emotions across species
Since the 19th century, there has been disagreement over the fundamental question of
whether" emotions" are cause or consequence of their associated behaviors. This question …
whether" emotions" are cause or consequence of their associated behaviors. This question …
Imaging calcium in neurons
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
NeuroPAL: a multicolor atlas for whole-brain neuronal identification in C. elegans
Comprehensively resolving neuronal identities in whole-brain images is a major challenge.
We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a …
We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a …
Global brain dynamics embed the motor command sequence of Caenorhabditis elegans
While isolated motor actions can be correlated with activities of neuronal networks, an
unresolved problem is how the brain assembles these activities into organized behaviors …
unresolved problem is how the brain assembles these activities into organized behaviors …
Whole-brain serial-section electron microscopy in larval zebrafish
High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …
An optimized fluorescent probe for visualizing glutamate neurotransmission
We describe an intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) with
signal-to-noise ratio and kinetics appropriate for in vivo imaging. We engineered iGluSnFR …
signal-to-noise ratio and kinetics appropriate for in vivo imaging. We engineered iGluSnFR …
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans
A major challenge in neuroscience is to reliably activate individual neurons, particularly
those in deeper brain regions. Current optogenetic approaches require invasive surgical …
those in deeper brain regions. Current optogenetic approaches require invasive surgical …
Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans
The ability to acquire large-scale recordings of neuronal activity in awake and unrestrained
animals is needed to provide new insights into how populations of neurons generate animal …
animals is needed to provide new insights into how populations of neurons generate animal …
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Genetically encoded calcium indicators (GECIs) can be used to image activity in defined
neuronal populations. However, current GECIs produce inferior signals compared to …
neuronal populations. However, current GECIs produce inferior signals compared to …
Chemosensory signal transduction in Caenorhabditis elegans
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …
tastants, and pheromones, into information that drives attraction or avoidance motor …