ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

The failure of proteins to penetrate mammalian cells or target tumor cells restricts their value
as therapeutic tools in a variety of diseases such as cancers. Recently, protein transduction …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Novel effective drugs or therapeutic vaccines have been already developed to eradicate
viral infections. Some non-viral carriers have been used for effective drug delivery to a target …

Therapeutic proteins provided new opportunities for patients and high sales volumes.
However, they are formulated for extracellular targets. The lipophilic barrier of the plasma …

Therapeutic proteins can face substantial challenges to their activity, requiring protein
modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of …

The design of a non-viral gene delivery system that can release a functional nucleic acid at
the intracellular destination site is an exciting but also challenging proposition. The ideal …

The cryopreservation of cells underpins many areas of biotechnology, healthcare, and
fundamental science by enabling the banking and distribution of cells. Cryoprotectants are …

Recombinant proteins with cytosolic or nuclear activities are emerging as tools for interfering
with cellular functions. Because such tools rely on vehicles for crossing the plasma …

Gene therapy is an emerging therapeutic strategy for the cure or treatment of a spectrum of
genetic disorders. Nevertheless, advances in gene therapy are immensely reliant upon …