An updated overview on the synthesis and anticancer evaluation of quinazoline derivatives

J Kaur, S Kaur, A Anand, N Islam, S Singh… - …, 2023 - Wiley Online Library
Cancer, a leading global cause of death, necessitates the exploration of safer and more
effective anticancer drugs due to the adverse side effects associated with current cytotoxic …

Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline

RL Rodríguez-Expósito, I Sifaoui, M Reyes-Batlle… - Antioxidants, 2023 - mdpi.com
Acanthamoeba is a ubiquitous genus of amoebae that can act as opportunistic parasites in
both humans and animals, causing a variety of ocular, nervous and dermal pathologies …

Natural Terpenes Inhibit the Cytopathogenicity of Naegleria fowleri Causing Primary Amoebic Meningoencephalitis in the Human Cell Line Model

K Rajendran, U Ahmed, AC Meunier… - ACS Chemical …, 2023 - ACS Publications
Naegleria fowleri is one of the free-living amoebae and is a causative agent of a lethal and
rare central nervous system infection called primary amoebic meningoencephalitis. Despite …

A comparative genomic approach to determine the virulence factors and horizontal gene transfer events of clinical Acanthamoeba isolates

X Gu, X Lu, S Lin, X Shi, Y Shen, Q Lu… - Microbiology …, 2022 - Am Soc Microbiol
Acanthamoeba species are among the most ubiquitous protists that are widespread in soil
and water and act as both a replicative niche and vectors for dispersal. They are the most …

Anti-amoebic effects of synthetic acridine-9 (10H)-one against brain-eating amoebae

U Ahmed, M Manzoor, S Qureshi, M Mazhar, A Fatima… - Acta Tropica, 2023 - Elsevier
Pathogenic A. castellanii and N. fowleri are opportunistic free-living amoebae.
Acanthamoeba spp. are the causative agents of granulomatous amebic encephalitis (GAE) …

Identification of 3, 4-dihydroxy complexes as potential antiviral via DFT, molecular docking, molecular dynamics and MM/PBSA against rabies and dengue receptors

P Sinha, AK Yadav - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
The quest to identify antiviral drug candidates for dengue and rabies viral diseases is a great
challenge for the researchers. While different research is being conducted on the …

Extracellular vesicles in parasitic diseases–from pathogenesis to future diagnostic tools

SA Menezes, T Tasca - Microbes and Infection, 2024 - Elsevier
Parasitic diseases are still a major public health problem especially among individuals of
low socioeconomic status in underdeveloped countries. In recent years it has been …

[HTML][HTML] Gongolarones as antiamoeboid chemical scaffold

RL Rodríguez-Expósito… - Biomedicine & …, 2023 - Elsevier
Abstract Free Living Amoeba (FLA) infections caused by Acanthamoeba genus include
chronic nervous system diseases such as Granulomatous Amoebic Encephalitis (GAE), or a …

Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones

U Ahmed, KY Ho, SE Simon, SM Saad, SK Ong… - Acta Tropica, 2022 - Elsevier
Acanthamoeba spp. are free living amoebae which can give rise to Acanthamoeba keratitis
and granulomatous amoebic encephalitis. The surface of Acanthamoeba contains …

Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii

U Ahmed, Y Sivasothy, KM Khan, NA Khan… - Acta Tropica, 2023 - Elsevier
Acanthamoeba castellanii is an opportunistic free-living amoeba (FLA) pathogen which can
cause fatal central nervous system (CNS) infection, granulomatous amoebic encephalitis …