Methylated natural products are widely spread in nature. S-Adenosyl-l-methionine (SAM) is
the secondary abundant cofactor and the primary methyl donor, which confer natural …

Mevalonate, an important intermediate product of the mevalonate pathway, has a broad
spectrum of applications. With the rapid growth of metabolic engineering and synthetic …

Cofactors are crucial chemicals that maintain cellular redox balance and drive the cell to do
synthetic and catabolic reactions. They are involved in practically all enzymatic activities that …

Synthetic biology is being increasingly used to establish novel carbon assimilation pathways
and artificial autotrophic strains that can be used in low-carbon biomanufacturing. Currently …

Utilization of microbial hosts to produce natural plant products is regarded as a promising
and sustainable approach. However, achieving highly efficient production of terpenoids …

Subcellular compartmentalization is a crucial evolution characteristic of eukaryotic cells,
providing inherent advantages for the construction of artificial biological systems to efficiently …

Linalool is one of the commercially important fragrance molecule usually extracted from
Lavandula angustifolia (lavender) and Ocimum basilicum (basil) plants. In the present study …

Acetaldehyde is a toxic pollutant that can be detoxified by acetaldehyde dehydrogenases
(ADAs) through its conversion to acetyl-CoA. This study developed an integrated approach …

Acyl‐CoAs are key precursors of primary and secondary metabolism. Their efficient
biosynthesis is often impeded by the limited substrate specificity and low in vivo activity of …

Terpenoids are a large variety of natural products with remarkable diverse biological
functions, and have a wide range of applications in flavors, pharmaceuticals, biofuels …