Most mammalian pre‐mRNA s are alternatively spliced in a manner that alters the resulting
open reading frame. Consequently, alternative pre‐mRNA splicing provides an important …

The bulk of AD research during the last 25 years has been Aβ-centric based on a strong faith
in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date …

Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …

The gene encoding a DNA/RNA binding protein FUS/TLS is frequently mutated in
amyotrophic lateral sclerosis (ALS). Mutations commonly affect its carboxy-terminal nuclear …

Fused in sarcoma (FUS) and splicing factor, proline-and glutamine-rich (SFPQ) are RNA
binding proteins that regulate RNA metabolism. We found that alternative splicing of the …

Genes specifically expressed in neurons contain members with extended long introns.
Longer genes present a problem with respect to fulfilment of gene length transcription, and …

Recent progress revealed the complexity of RNA processing and its association to human
disorders. Here, we unveil a new facet of this complexity. Complete loss of function of the …

ABSTRACT RNA-binding proteins (RBPs) play crucial roles in the functions and
homoeostasis of various tissues by regulating multiple events of RNA processing including …

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder in the elderly,
occurring in approximately 20% of people older than 80. The molecular causes of AD are …

The neuronal microtubule-associated protein tau is abnormally hyperphosphorylated and
aggregated into neurofibrillary tangles in the brains of individuals with Alzheimer's disease …