[HTML][HTML] Scattering approaches to unravel protein solution behaviors in ionic liquids and deep eutectic solvents: From basic principles to recent developments

Q Han, NVP Veríssimo, SJ Bryant, AV Martin… - Advances in Colloid and …, 2024 - Elsevier
Proteins in ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant
attention due to their potential applications in various fields, including biocatalysis …

Resonant soft X‐ray scattering in polymer science

BA Collins, E Gann - Journal of Polymer Science, 2022 - Wiley Online Library
Resonant soft X‐ray scattering (RSoXS) is an emerging, powerful technique to probe the
nano‐to‐mesoscale structure of polymers and other molecules. It joins together small‐angle …

Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer

JA Mattocks, JJ Jung, CY Lin, Z Dong, NH Yennawar… - Nature, 2023 - nature.com
Technologically critical rare-earth elements are notoriously difficult to separate, owing to
their subtle differences in ionic radius and coordination number,–. The natural lanthanide …

Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

TR Alderson, I Pritišanac, Đ Kolarić, AM Moses… - Proceedings of the …, 2023 - pnas.org
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

Cyclic nucleotide-induced helical structure activates a TIR immune effector

G Hogrel, A Guild, S Graham, H Rickman, S Grüschow… - Nature, 2022 - nature.com
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life.
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …

BioXTAS RAW 2: new developments for a free open-source program for small-angle scattering data reduction and analysis

JB Hopkins - Applied Crystallography, 2024 - journals.iucr.org
BioXTAS RAW is a free open-source program for reduction, analysis and modelling of
biological small-angle scattering data. Here, the new developments in RAW version 2 are …

Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry

T Dixon, D MacPherson, B Mostofian… - Nature …, 2022 - nature.com
Targeted protein degradation (TPD) is a promising approach in drug discovery for degrading
proteins implicated in diseases. A key step in this process is the formation of a ternary …

Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries

YX Tsai, NE Chang, K Reuter, HT Chang, TJ Yang… - Cell, 2024 - cell.com
Most membrane proteins are modified by covalent addition of complex sugars through N-
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …

Atomic resolution structure of full-length human insulin fibrils

S Suladze, R Sarkar, N Rodina, K Bokvist… - Proceedings of the …, 2024 - pnas.org
Patients with type 1 diabetes mellitus who are dependent on an external supply of insulin
develop insulin-derived amyloidosis at the sites of insulin injection. A major component of …

Overcoming universal restrictions on metal selectivity by protein design

TS Choi, FA Tezcan - Nature, 2022 - nature.com
Selective metal coordination is central to the functions of metalloproteins:, each
metalloprotein must pair with its cognate metallocofactor to fulfil its biological role. However …