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[HTML][HTML] Scattering approaches to unravel protein solution behaviors in ionic liquids and deep eutectic solvents: From basic principles to recent developments
Proteins in ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant
attention due to their potential applications in various fields, including biocatalysis …
attention due to their potential applications in various fields, including biocatalysis …
Resonant soft X‐ray scattering in polymer science
Resonant soft X‐ray scattering (RSoXS) is an emerging, powerful technique to probe the
nano‐to‐mesoscale structure of polymers and other molecules. It joins together small‐angle …
nano‐to‐mesoscale structure of polymers and other molecules. It joins together small‐angle …
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
Technologically critical rare-earth elements are notoriously difficult to separate, owing to
their subtle differences in ionic radius and coordination number,–. The natural lanthanide …
their subtle differences in ionic radius and coordination number,–. The natural lanthanide …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Cyclic nucleotide-induced helical structure activates a TIR immune effector
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life.
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …
BioXTAS RAW 2: new developments for a free open-source program for small-angle scattering data reduction and analysis
JB Hopkins - Applied Crystallography, 2024 - journals.iucr.org
BioXTAS RAW is a free open-source program for reduction, analysis and modelling of
biological small-angle scattering data. Here, the new developments in RAW version 2 are …
biological small-angle scattering data. Here, the new developments in RAW version 2 are …
Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry
Targeted protein degradation (TPD) is a promising approach in drug discovery for degrading
proteins implicated in diseases. A key step in this process is the formation of a ternary …
proteins implicated in diseases. A key step in this process is the formation of a ternary …
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries
Most membrane proteins are modified by covalent addition of complex sugars through N-
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
Atomic resolution structure of full-length human insulin fibrils
Patients with type 1 diabetes mellitus who are dependent on an external supply of insulin
develop insulin-derived amyloidosis at the sites of insulin injection. A major component of …
develop insulin-derived amyloidosis at the sites of insulin injection. A major component of …
Overcoming universal restrictions on metal selectivity by protein design
Selective metal coordination is central to the functions of metalloproteins:, each
metalloprotein must pair with its cognate metallocofactor to fulfil its biological role. However …
metalloprotein must pair with its cognate metallocofactor to fulfil its biological role. However …