Interleukin-1 family cytokines: keystones in liver inflammatory diseases

L Barbier, M Ferhat, E Salamé, A Robin… - Frontiers in …, 2019‏ - frontiersin.org
The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

Soluble ST2 in heart failure

B Dieplinger, T Mueller - Clinica Chimica Acta, 2015‏ - Elsevier
In addition to routine clinical laboratory tests (including natriuretic peptides and cardiac
troponins), other biomarkers are gaining attention for their utility in heart failure (HF) …

[HTML][HTML] Elevated levels of IL-33, IL-17 and IL-25 indicate the progression from chronicity to hepatocellular carcinoma in hepatitis C virus patients

M Askoura, HA Abbas, H Al Sadoun, WH Abdulaal… - Pathogens, 2022‏ - mdpi.com
Hepatitis C virus (HCV) is one of the most epidemic viral infections in the world. Three-
quarters of individuals infected with HCV become chronic. As a consequence of persistent …

Soluble ST2—analytical considerations

T Mueller, AS Jaffe - The American journal of cardiology, 2015‏ - Elsevier
Suppression of tumorigenicity 2 (ST2, also known as interleukin [IL]-1 receptor–like-1) is an
IL-1 receptor family member with transmembrane (ST2L) and soluble isoforms (sST2). ST2L …

Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases

O Rostan, MI Arshad, C Piquet-Pellorce… - Infection and …, 2015‏ - journals.asm.org
ABSTRACT Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and
pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by …

NLRP3 inflammasome and IL-33: novel players in sterile liver inflammation

K Neumann, B Schiller, G Tiegs - International journal of molecular …, 2018‏ - mdpi.com
In sterile liver inflammation, danger signals are released in response to tissue injury to alert
the immune system; eg, by activation of the NLRP3 inflammasome. Recently, IL-33 has been …

IL-33 induces nuocytes and modulates liver injury in viral hepatitis

Y Liang, Z Jie, L Hou, R Aguilar-Valenzuela… - The Journal of …, 2013‏ - journals.aai.org
Molecules containing damage-associated molecular patterns play an important role in many
pathogenic processes. In this study, our aim was to investigate the role of IL-33, a damage …

Dichotomous function of IL-33 in health and disease: from biology to clinical implications

H Braun, IS Afonina, C Mueller, R Beyaert - Biochemical Pharmacology, 2018‏ - Elsevier
Abstract Interleukin (IL)-33 is a cytokine that is released from epithelial and endothelial cells
at barrier surfaces upon tissue stress or damage to operate as an alarmin. IL-33 has been …

A proinflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

K Neumann, K Karimi, J Meiners… - The Journal of …, 2017‏ - journals.aai.org
Type 2 innate lymphoid cells (ILC2) mediate inflammatory immune responses in the context
of diseases triggered by the alarmin IL-33. In recent years, IL-33 has been implicated in the …

The dynamic role of the IL-33/ST2 axis in chronic viral-infections: alarming and adjuvanting the immune response

V Mehraj, R Ponte, JP Routy - EBioMedicine, 2016‏ - thelancet.com
Abstract Interleukin 33 (IL-33), a member of the IL-1 family, is constitutively expressed in
epithelial and in endothelial cells at barrier sites, acting as a danger signal and adjuvanting …