Probiotics mechanism of action on immune cells and beneficial effects on human health
Immune cells and commensal microbes in the human intestine constantly communicate with
and react to each other in a stable environment in order to maintain healthy immune …
and react to each other in a stable environment in order to maintain healthy immune …
Advanced molecular and immunological diagnostic methods to detect SARS-CoV-2 infection
Simple Summary COVID-19 emerged in late 2019 in China and rapidly spread across the
globe. After 2 years, numerous advances have been made. First of all, the preventive …
globe. After 2 years, numerous advances have been made. First of all, the preventive …
[HTML][HTML] Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation
Human osteogenic differentiation is a complex and well-orchestrated process which
involves a plethora of molecular players and cellular processes. A growing number of …
involves a plethora of molecular players and cellular processes. A growing number of …
Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms
There is a growing interest to understand the role and mechanism of action of microRNAs
(miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that …
(miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that …
Alternatively spliced isoforms of the P2X7 receptor: structure, function and disease associations
SKF De Salis, L Li, Z Chen, KW Lam… - International Journal of …, 2022 - mdpi.com
The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by
multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad …
multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad …
Neuropathic pain: Mechanisms and therapeutic strategies
The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …
Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy
H Zalpoor, A Akbari, M Nabi-Afjadi… - Human Cell, 2022 - Springer
Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is a neuroinvasive virus. According to the centers for disease control and prevention …
2) is a neuroinvasive virus. According to the centers for disease control and prevention …
P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma
Glioblastomas are highly aggressive and deadly brain tumours, with a median survival time
of 14–18 months post-diagnosis. Current treatment modalities are limited and only modestly …
of 14–18 months post-diagnosis. Current treatment modalities are limited and only modestly …
Animal models for the investigation of P2X7 receptors
The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular
adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of …
adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of …
Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury
R Zhang, K Su, L Yang, M Tang, M Zhao… - Journal of Medicinal …, 2023 - ACS Publications
Sepsis-associated acute kidney injury (AKI) is a serious clinical problem, without effective
drugs. Abnormal activation of the purinergic P2X7 receptor (P2X7R) in septic kidneys makes …
drugs. Abnormal activation of the purinergic P2X7 receptor (P2X7R) in septic kidneys makes …