Rational design in photopharmacology with molecular photoswitches

P Kobauri, FJ Dekker, W Szymanski… - Angewandte Chemie …, 2023 - Wiley Online Library
Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Isomerization of bioactive acylhydrazones triggered by light or thiols

Z Zhang, GNT Le, Y Ge, X Tang, X Chen, L Ejim… - Nature Chemistry, 2023 - nature.com
The acylhydrazone unit is well represented in screening databases used to find ligands for
biological targets, and numerous bioactive acylhydrazones have been reported. However …

Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light

C Geoffroy, R Berraud-Pache, N Chéron… - ACS Chemical …, 2024 - ACS Publications
NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in
synaptic transmission and plasticity. NMDAR dysregulation is linked to various …

Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

K Roßmann, AJ Gonzalez‐Hernandez… - Angewandte …, 2024 - Wiley Online Library
Chemical photoswitches have become a widely used approach for the remote control of
biological functions with spatiotemporal precision. Several molecular scaffolds have been …

A photochromic salicylaldehyde hydrazone derivative based on CN isomerization and ESIPT mechanisms and its detection of Al3+ in aqueous solution

L Yan, H Yang, N Liu, F Meng, S Zhang - Spectrochimica Acta Part A …, 2022 - Elsevier
A simple photochromic Schiff base was successfully prepared by the condensation of
salicylaldehyde and benzoyl hydrazine. This compound has reversible photochromic …

Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives

M Nikolaev, D Tikhonov - International Journal of Molecular Sciences, 2023 - mdpi.com
Glutamate ionotropic receptors mediate fast excitation processes in the central nervous
system of vertebrates and play an important role in synaptic plasticity, learning, and memory …

Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer

C Breton‐Patient, S Billotte, P Duchambon… - …, 2024 - Wiley Online Library
Photopharmacology is an emerging field that utilizes photo‐responsive molecules to enable
control over the activity of a drug using light. The aim is to limit the therapeutic action of a …

Design of Soluble Compounds for Optical Control of Tetrameric P-Loop Ion Channels

ED Gataulina, MV Nikolaev, DB Tikhonov - Journal of Evolutionary …, 2024 - Springer
The photopharmacology of ion channels is a rapidly develo** area. One reason for paying
special attention to the design of photoswitchable ligands for ion channels is that the …

Reversible inhibition of GluN2B-containing NMDA receptors with an in situ red-shifted, photoswitchable antagonist

C Geoffroy, R Berraud-Pache, N Chéron… - bioRxiv, 2023 - biorxiv.org
NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in
synaptic transmission and plasticity. Dysregulation of NMDARs is linked to various …