Rational design in photopharmacology with molecular photoswitches
Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
Isomerization of bioactive acylhydrazones triggered by light or thiols
The acylhydrazone unit is well represented in screening databases used to find ligands for
biological targets, and numerous bioactive acylhydrazones have been reported. However …
biological targets, and numerous bioactive acylhydrazones have been reported. However …
Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light
NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in
synaptic transmission and plasticity. NMDAR dysregulation is linked to various …
synaptic transmission and plasticity. NMDAR dysregulation is linked to various …
Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology
K Roßmann, AJ Gonzalez‐Hernandez… - Angewandte …, 2024 - Wiley Online Library
Chemical photoswitches have become a widely used approach for the remote control of
biological functions with spatiotemporal precision. Several molecular scaffolds have been …
biological functions with spatiotemporal precision. Several molecular scaffolds have been …
A photochromic salicylaldehyde hydrazone derivative based on CN isomerization and ESIPT mechanisms and its detection of Al3+ in aqueous solution
L Yan, H Yang, N Liu, F Meng, S Zhang - Spectrochimica Acta Part A …, 2022 - Elsevier
A simple photochromic Schiff base was successfully prepared by the condensation of
salicylaldehyde and benzoyl hydrazine. This compound has reversible photochromic …
salicylaldehyde and benzoyl hydrazine. This compound has reversible photochromic …
Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives
M Nikolaev, D Tikhonov - International Journal of Molecular Sciences, 2023 - mdpi.com
Glutamate ionotropic receptors mediate fast excitation processes in the central nervous
system of vertebrates and play an important role in synaptic plasticity, learning, and memory …
system of vertebrates and play an important role in synaptic plasticity, learning, and memory …
Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer
C Breton‐Patient, S Billotte, P Duchambon… - …, 2024 - Wiley Online Library
Photopharmacology is an emerging field that utilizes photo‐responsive molecules to enable
control over the activity of a drug using light. The aim is to limit the therapeutic action of a …
control over the activity of a drug using light. The aim is to limit the therapeutic action of a …
Design of Soluble Compounds for Optical Control of Tetrameric P-Loop Ion Channels
ED Gataulina, MV Nikolaev, DB Tikhonov - Journal of Evolutionary …, 2024 - Springer
The photopharmacology of ion channels is a rapidly develo** area. One reason for paying
special attention to the design of photoswitchable ligands for ion channels is that the …
special attention to the design of photoswitchable ligands for ion channels is that the …
Reversible inhibition of GluN2B-containing NMDA receptors with an in situ red-shifted, photoswitchable antagonist
NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in
synaptic transmission and plasticity. Dysregulation of NMDARs is linked to various …
synaptic transmission and plasticity. Dysregulation of NMDARs is linked to various …