Clinical tools and biomarkers to predict preeclampsia

TM MacDonald, SP Walker, NJ Hannan, S Tong… - …, 2022 - thelancet.com
Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal
morbidity and mortality worldwide. An effective predictive test for preeclampsia would …

Secretory products of the corpus luteum and preeclampsia

MM Pereira, M Mainigi… - Human Reproduction …, 2021 - academic.oup.com
BACKGROUND Despite significant advances in our understanding of the pathophysiology
of preeclampsia (PE), there are still many unknowns and controversies in the field. Women …

Early prediction and longitudinal modeling of preeclampsia from multiomics

I Marić, K Contrepois, MN Moufarrej, IA Stelzer… - Patterns, 2022 - cell.com
Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear.
We developed machine-learning models for early prediction of preeclampsia (first 16 weeks …

Single cell transcriptome research in human placenta

H Li, Q Huang, Y Liu, LX Garmire - Reproduction, 2020 - rep.bioscientifica.com
Human placenta is a complex and heterogeneous organ interfacing between the mother
and the fetus that supports fetal development. Alterations to placental structural components …

Omics approaches to study formation and function of human placental syncytiotrophoblast

A Jaremek, MJ Jeyarajah, G Jaju Bhattad… - Frontiers in Cell and …, 2021 - frontiersin.org
Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

Genetic background of fetal growth restriction

BA Nowakowska, K Pankiewicz, U Nowacka… - International Journal of …, 2021 - mdpi.com
Fetal growth restriction (FGR) is one of the most formidable challenges in present-day
antenatal care. Pathological fetal growth is a well-known factor of not only in utero demise in …

Pre-eclampsia: A sco** review of risk factors and suggestions for future research direction

K Lee, L Brayboy, A Tripathi - Regenerative Engineering and Translational …, 2022 - Springer
Most of maternal deaths are preventable, and one-quarter of maternal deaths are due to pre-
eclampsia and eclampsia. Prenatal screening is essential for detecting and managing pre …

Placental microarray profiling reveals common mRNA and lncRNA expression patterns in preeclampsia and intrauterine growth restriction

D Medina-Bastidas, M Guzmán-Huerta… - International journal of …, 2020 - mdpi.com
Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are major contributors to
perinatal morbidity and mortality. These pregnancy disorders are associated with placental …

Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

L Youssef, RV Simões, J Miranda, ML García-Martín… - Scientific Reports, 2021 - nature.com
Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders
with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in …

The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

B He, Y Liu, MR Maurya, P Benny, C Lassiter, H Li… - Journal of lipid …, 2021 - ASBMB
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and
proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are …