The H1N1 influenza pandemic of 2009 has claimed over 18,000 lives. During this pandemic,
development of drug resistance further complicated efforts to control and treat the …

Repeated cycles of antibody-directed enzyme pro-drug therapy (ADEPT) and the use of
glucarpidase in the detoxification of cytotoxic methotrexate (MTX) are highly desirable …

Type 2 diabetes mellitus (T2DM) stands as a prevalent global public health issue caused by
deficiencies in the action of insulin and/or insulin production. In the liver, insulin plays an …

The enzyme carboxypeptidase G2 (CPG2) is used in antibody‐directed enzyme prodrug
therapy (ADEPT) to catalyse the formation of an active drug from an inert prodrug. Free …

Poly (aspartic acid)(PAA) is a common water-soluble polycarboxylate used in a broad range
of applications. PAA biodegradation and environmental assimilation were first identified in …

This dissertation describes the work towards phosphorylation-based proteolytic logic
circuitry, computational design and structure of flexible protein assemblies, and the …

Conventional cancer therapies such as Radiotherapy, chemotherapy and surgery are often
associated with severe side effects due to the lack of specificity to tumor cells. Targeted …

University of Groningen Production of novel protein therapeutics to improve targeted cancer
therapy Al-Qahtani, Alanod Page 1 University of Groningen Production of novel protein …

Methotrexate is one of widely used anti-cancer agent. High-dose methotrexate (HDMTX)
followed by leucovorin rescue therapy is an important component in the treatment of a …

The antibody directed enzyme pro-drug therapy (ADEPT) is a new anticancer treatment,
where pre-clinical experiments concluded that an intermediate step involving the inhibition …