Iron homeostasis in health and disease

R Gozzelino, P Arosio - International journal of molecular sciences, 2016 - mdpi.com
Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its
homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen …

Physiology and inflammation driven pathophysiology of iron homeostasis—mechanistic insights into anemia of inflammation and its treatment

L Lanser, D Fuchs, K Kurz, G Weiss - Nutrients, 2021 - mdpi.com
Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

[PDF][PDF] Федеральные клинические рекомендации по диагностике и лечению железодефицитной анемии

АГ Румянцев, АА Масчан, ВМ Чернов, ИС Тарасова - Москва, 2015 - researchgate.net
Эндокринная офтальмопатия (ЭОП)—мультидисциплинарная проблема, находящаяся
на стыке эндокринологии и офтальмологии. Помощь больным с ЭОП недостаточна …

Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression

Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan… - Cell, 2018 - cell.com
Identifying tumor-induced leukocyte subsets and their derived circulating factors has been
instrumental in understanding cancer as a systemic disease. Nevertheless, how primary …

Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial

JP De Almeida, JL Vincent, FRBG Galas… - Survey of …, 2015 - journals.lww.com
For patients with solid tumors, surgery is often the main treat-ment, but the issue of the
potential benefits and risks of red blood cell (RBC) transfusions during surgery remains …

Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …

MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …

[HTML][HTML] Lactate modulates iron metabolism by binding soluble adenylyl cyclase

W Liu, S Zhang, Q Li, Y Wu, X Jia, W Feng, Z Li, Y Shi… - Cell Metabolism, 2023 - cell.com
Overproduction of lactate (LA) can occur during exercise and in many diseases such as
cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and …

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1

L Zhou, D Wu, Y Zhou, D Wang, H Fu, Q Huang… - Nature …, 2023 - nature.com
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in
individuals with cancer; however, such factors have not yet been identified. Here we show …

Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment

G Capuano, PC Gentile, F Bianciardi, M Tosti… - Supportive care in …, 2010 - Springer
Goals of work The aim of this study was to evaluate the prevalence and influence of
malnutrition (unintentional weight loss≥ 5% in the last 3 months) on quality of life (QoL) and …

Lower pretreatment hemoglobin status and treatment breaks in locally advanced head and neck squamous cell carcinoma during concurrent chemoradiation

RK Narayanasamy, RM Muthusekar… - Indian journal of …, 2021 - journals.lww.com
Background: Treatment breaks during radiation for locally advanced Head and Neck
Squamous Cell Carcinoma (HNSCC) is one of the important factors affecting the loco …