Accumulating evidence supports not only the functional role of the gut microbiome in cancer
development and progression but also its role in defining the efficacy and toxicity of …

Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …

The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase,
which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis. Depletion of …

The inception of cancer treatment with chemotherapeutics began in the 1940s with nitrogen
mustards that were initially employed as weapons in World War II. Since then, treatment …

Vitamins with antioxidant characteristics have been shown as potential chemopreventive
agents because of their roles in quenching free radicals and decreasing oxidative damage …

Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and
its third main cause is drug toxicity. Nephrotoxicity can be defined as any renal injury caused …

Dose-limiting toxicity and significant patient-to-patient pharmacokinetic variability often
render it difficult to achieve the safe and effective dosing of drugs. This is further …

A 3D printing technique has been developed which enables the treatment of osteosarcoma
via personalized local chemotherapy. A series of in vivo trials were conducted which closely …

Since its discovery in 1945, methotrexate has become a standard therapy for number of
diseases, including oncological, inflammatory and pulmonary ones. Major physiological …

Folate-mediated one carbon (1C) metabolism supports a series of processes that are
essential for the cell. Through a number of interlinked reactions happening in the cytosol …