Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Cancer stem cells (CSCs) are a unique population in the tumor, but they only comprise 2%–
5% of the tumor bulk. Although CSCs share several features with embryonic stem cells …

Molecular biomarkers that interact with the vascular and immune compartments play an
important role in the progression of solid malignancies. CD105, which is a component of the …

Cancer is one of the deadliest diseases in the world. Despite extensive studies, treating
metastatic cancers remains challenging. Years of research have linked a rare set of cells …

Targeting tumor-associated angiogenesis is currently at the forefront of renal cell carcinoma
(RCC) therapy, with sunitinib and bevacizumab leading to increased survival in patients with …

Cancer stem cells (CSCs) play an important role in cancer development. Based on
advancements in CSC research, we propose a monophyletic model of cancer. This model is …

Cancer is one of the diseases with the highest morbidity and mortality rates worldwide, and
its therapeutic options are inadequate. The endothelial glycoprotein, also known as CD105 …

Sirtuins (SIRTs) are stress-responsive proteins that regulate several post-translational
modifications, partly by acetylation, deacetylation, and affecting DNA methylation. As a …

Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer. Prognosis for
ccRCC is generally poor since it is largely resistant to chemo-and radiotherapy. Many …

Early clinical studies indicated that estrogen receptor beta (ERβ) might play key roles to
impact the progression of clear cell renal cell carcinoma (ccRCC). The detailed molecular …