Similar to dementia, the risk for develo** type 2 diabetes mellitus (T2DM) increases with
age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD) …

Diabetes mellitus, also known simply as diabetes, has been described as a chronic and
complex endocrine metabolic disorder that is a leading cause of death across the globe. It is …

Rationale: In observational studies, type 2 diabetes mellitus (T2D) has been associated with
an increased risk of hypertension, and vice versa; however, the causality between these …

Gene set enrichment tests (aka functional enrichment analysis) are among the most
frequently used methods in computational biology. Despite this popularity, there are …

Socioeconomic status (SES) impacts health and life-course outcomes. This genome-wide
association study (GWAS) of sociologically informed occupational status measures (ISEI …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

Abstract Background Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in
NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal …

Objective To assess the causal effect of type 2 diabetes mellitus (T2DM) on male infertility
(MI) and erectile dysfunction (ED) by Mendelian randomization (MR) analysis. Methods Data …

Purpose: Introns play an important role in gene regulation and expression. Single nucleotide
polymorphisms (SNPs) in introns have the potential to cause disease and alter the genotype …

Here, we describe a dataset with information about monogenic, rare diseases with a known
genetic background, supplemented with manually extracted provenance for the disease …