The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …

The NLRP 3 (NOD‐like receptor family, pyrin domain containing 3) inflammasome is a
multiprotein complex that orchestrates innate immune responses to infection and cell stress …