Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …

Caspases are cysteine proteases that play important and well-defined roles in apoptosis
and inflammation. Increasing evidence point to alternative functions of caspases where …

The circuitry of the brain is characterized by cell heterogeneity, sprawling cellular anatomy,
and astonishingly complex patterns of connectivity. Determining how complex neural circuits …

The homeoprotein family comprises~ 300 transcription factors and was long seen as
primarily involved in developmental programs through cell autonomous regulation …

The pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN) is poorly
understood. Here, we report that the CIPN-causing drug bortezomib (Bort) promotes delta 2 …

Neurons face a series of morphological and molecular changes following trauma and in the
progression of neurodegenerative disease. In neurons capable of mounting a spontaneous …

Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic
dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection …

Neurovascular disorders, which involve the vascular and nervous systems, are common.
Research on such disorders usually focuses on either vascular or nervous components …

Kinetochores connect centromeric chromatin to spindle microtubules during mitosis.
Neurons are postmitotic, so it was surprising to identify transcripts of structural kinetochore …