The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

The past decade has witnessed a rapid growth in understanding of the pivotal roles of
mechanical stresses and physical forces in cell biology. As a result, an integrated view of …

Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …

The interrelationship between microtubules and the actin cytoskeleton in
mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show …

Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …

Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …

Contractile actomyosin networks are responsible for the production of intracellular forces.
There is increasing evidence that bundles of actin filaments form interconnected and …

Cytoskeletal mechanics regulates cell morphodynamics and many physiological processes.
While contractility is known to be largely RhoA-dependent, the process by which localized …