The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …

This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …

Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular
heterogeneity and the dynamics of gene expression, bearing profound significance in stem …

Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged
as a promising strategy to remuscularize injured myocardium. However, it is insufficient to …

Single-cell RNA sequencing (scRNA-seq) technology is a powerful, rapidly develo** tool
for characterizing individual cells and elucidating biological mechanisms at the cellular …

Direct reprogramming has revolutionized the fields of stem cell biology and regenerative
medicine. However, the common mechanisms governing how reprogramming cells undergo …

Defining the mechanisms safeguarding cell fate identity in differentiated cells is crucial to
improve 1)-our understanding of how differentiation is maintained in healthy tissues or …