Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration
Neuroinflammation has either beneficial or detrimental effects, depending on risk factors and
neuron–glia interactions in neurological disorders. However, studying neuroinflammation …
neuron–glia interactions in neurological disorders. However, studying neuroinflammation …
[HTML][HTML] Chemical update on the potential for serotonin 5-HT6 and 5-HT7 receptor agents in the treatment of Alzheimer's disease
K Kucwaj-Brysz, H Baltrukevich, K Czarnota… - Bioorganic & Medicinal …, 2021 - Elsevier
Despite the better understanding of the mechanisms underlying Alzheimer's Disease (AD)
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …
Gut-derived β-amyloid: Likely a centerpiece of the gut–brain axis contributing to Alzheimer's pathogenesis
J **, Z Xu, L Zhang, C Zhang, X Zhao, Y Mao… - Gut …, 2023 - Taylor & Francis
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …
An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models
Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation …
highlights as a global health concern. Several epidemiological studies show the correlation …
Masitinib for mild-to-moderate Alzheimer's disease: results from a randomized, placebo-controlled, phase 3, clinical trial
B Dubois, J López-Arrieta, S Lipschitz, T Doskas… - Alzheimer's Research & …, 2023 - Springer
Background Masitinib is an orally administered tyrosine kinase inhibitor that targets
activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 …
activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 …
[HTML][HTML] Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline and memory loss. While the precise causes of AD remain unclear …
cognitive decline and memory loss. While the precise causes of AD remain unclear …
Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease
Microglial neuroinflammation appears to be neuroprotective in the early pathological stage,
yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD) …
yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD) …
Critical appraisal on mitochondrial dysfunction in Alzheimer's disease
It is widely recognized that Alzheimer's disease (AD) is a common type of progressive
neurodegenerative disorder that results in cognitive impairment over time. Approximately …
neurodegenerative disorder that results in cognitive impairment over time. Approximately …
Oral pathogenic bacteria-inducing neurodegenerative microgliosis in human neural cell platform
Porphyromonas gingivalis is a gram-negative bacterium found in the human oral cavity and
is responsible for the development of chronic periodontitis as well as neurological diseases …
is responsible for the development of chronic periodontitis as well as neurological diseases …
Personalizing the care and treatment of Alzheimer's disease: an overview
Alzheimer's disease (AD) is a progressive, complex, and multifactorial neurodegenerative
disorder, still without effective and stable therapeutic strategies. Currently, available …
disorder, still without effective and stable therapeutic strategies. Currently, available …