Phosphate linkages govern life as we know it. Their unique properties provide the
foundation for many natural systems from cell biology and biosynthesis to the backbone of …

Peptide and protein selective modification at tyrosine residues has become an exploding
field of research as tyrosine constitutes a robust alternative to lysine and cysteine-targeted …

RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet
current manufacturing methods may not be able to deliver on anticipated future demand …

Therapeutic oligonucleotides have emerged as a powerful drug modality with the potential
to treat a wide range of diseases; however, the rising number of therapies poses a …

Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and
phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of …

Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry;
however, the use of such compounds as tools or medicinal leads for nucleotide-dependent …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

Molecules that contain a stereogenic phosphorus atom are crucial to medicine,
agrochemistry and catalysis. While methods are available for the selective construction of …

Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …

P‐stereogenic compounds are widely used as ligands in asymmetric catalysis and are
present in a myriad of bioactive compounds and pharmaceuticals. Yet, their stereocontrolled …