The XRN family of 5′→ 3′ exoribonucleases is critical for ensuring the fidelity of cellular
RNA turnover in eukaryotes. Highly conserved across species, the family is typically …

As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …

The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5′-end capped
RNAs is now well established. Nevertheless, the biological function of this nucleotide …

Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a
temporary non-proliferating state. Although central for a variety of essential processes …

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease
resulting from pathologically low levels of survival motor neuron (SMN) protein. The majority …

What has been will be again, what has been done will be done again; there is nothing new
under the sun.—Ecclesiastes 1: 9 (New International Version) Posttranscriptional regulation …

Eukaryotic 5′ mRNA cap structures participate to the post-transcriptional control of gene
expression before being released by the two main mRNA decay pathways. In the 3′-5 …

In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes
required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a …

Stresses, such as glucose depletion, activate Snf1, the Saccharomyces cerevisiae ortholog
of adenosine monophosphate–activated protein kinase (AMPK), enabling adaptive cellular …

The accurate biogenesis of RNA–protein complexes is a key aspect of eukaryotic cells.
Defects in Sm protein complex binding to snRNAs are known to reduce levels of snRNAs …