A review of progress in single particle tracking: from methods to biophysical insights

C Manzo, MF Garcia-Parajo - Reports on progress in physics, 2015 - iopscience.iop.org
Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Anomalous diffusion, aging, and nonergodicity of scaled Brownian motion with fractional Gaussian noise: Overview of related experimental observations and models

W Wang, R Metzler, AG Cherstvy - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
How does a systematic time-dependence of the diffusion coefficient D (t) affect the ergodic
and statistical characteristics of fractional Brownian motion (FBM)? Here, we answer this …

Objective comparison of methods to decode anomalous diffusion

G Muñoz-Gil, G Volpe, MA Garcia-March… - Nature …, 2021 - nature.com
Deviations from Brownian motion leading to anomalous diffusion are found in transport
dynamics from quantum physics to life sciences. The characterization of anomalous diffusion …

Brownian yet non-Gaussian diffusion: from superstatistics to subordination of diffusing diffusivities

AV Chechkin, F Seno, R Metzler, IM Sokolov - Physical Review X, 2017 - APS
A growing number of biological, soft, and active matter systems are observed to exhibit
normal diffusive dynamics with a linear growth of the mean-squared displacement, yet with a …

Bayesian deep learning for error estimation in the analysis of anomalous diffusion

H Seckler, R Metzler - Nature Communications, 2022 - nature.com
Modern single-particle-tracking techniques produce extensive time-series of diffusive motion
in a wide variety of systems, from single-molecule motion in living-cells to movement …

Matrix mechanics and water permeation regulate extracellular vesicle transport

S Lenzini, R Bargi, G Chung, JW Shin - Nature nanotechnology, 2020 - nature.com
Cells release extracellular vesicles (EVs) to communicate over long distances, which
requires EVs to traverse the extracellular matrix (ECM). However, given that the size of EVs …

Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins

JH Jeon, M Javanainen, H Martinez-Seara, R Metzler… - Physical Review X, 2016 - APS
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

Anomalous diffusion, nonergodicity, non-Gaussianity, and aging of fractional Brownian motion with nonlinear clocks

Y Liang, W Wang, R Metzler, AG Cherstvy - Physical Review E, 2023 - APS
How do nonlinear clocks in time and/or space affect the fundamental properties of a
stochastic process? Specifically, how precisely may ergodic processes such as fractional …

Manipulation and motion of organelles and single molecules in living cells

K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …

Heterogeneous anomalous transport in cellular and molecular biology

TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …