Angiogenesis or formation of new blood vessels from preexisting vasculature is a key
process in some physiological conditions such as wound healing, growth, and action of …

The increasing percentage of obese individuals in the population and its independent
association of increased risk for the development of cancer have heightened the necessity to …

The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but
because only a percentage of patients are responsive to immunotherapy, it is imperative to …

Lifestyle factors, including diet, play an important role in the survival of cancer patients.
However, the molecular mechanisms underlying pathogenic links between diet and …

The acquired ability to induce the formation of a functional vasculature is a hallmark of
cancer. Blood vessels in tumors are formed through various mechanisms, among the most …

Obesity is a major health burden with an increased risk of cardiovascular morbidity and
mortality. Endothelial dysfunction is pivotal to the development of cardiovascular disease …

Background Dysfunctional mitochondrial processes limit malignant cells ability to use
energy from fatty acids and ketones. Animal studies using ketogenic diets for cancer show …

Background One of the factors that affect the progression of melanoma is the tumor
microenvironment, which consists of cellular elements, extracellular matrix, acidification, and …

Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

The dramatic increases in incidence of both obesity and many cancers including skin cancer
emphasize the need to better understand the pathophysiology of both conditions and their …