After induction and specification in the ectoderm, at the border of the neural plate, the neural
crest (NC) population leaves its original territory through a delamination process. Soon …

The muscle satellite cell was first described and actually named on the basis of its anatomic
location under the basement membrane surrounding each myofiber. For many years …

The embryonic head is populated by two robust mesenchymal populations, paraxial
mesoderm and neural crest cells. Although the developmental histories of each are distinct …

Genetic regulatory networks governing skeletal myogenesis in the body are well
understood, yet their hierarchical relationships in the head remain unresolved. We show that …

Development of the vertebrate skeleton, a complex biological event that includes diverse
processes such as formation of mesenchymal condensations at the sites of future skeletal …

Unraveling the complex tissue interactions necessary to generate the structural and
functional diversity present among craniofacial muscles is challenging. These muscles …

The Wnt/β-catenin signaling pathway is one of several key conserved intercellular signaling
pathways in animals, and plays fundamental roles in the proliferation, regeneration …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

In mammals, Six5, Six4 and Six1 genes are co-expressed during mouse myogenesis. Six4
and Six5 single knockout (KO) mice have no developmental defects, while Six1 KO mice die …

The molecular, genetic and cellular bases for skeletal muscle growth and regeneration have
been recently documented in a number of vertebrate species. These studies highlight the …