The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …
Understanding the mechanisms of recovery and/or compensation following injury
Injury due to stroke and traumatic brain injury result in significant long‐term effects upon
behavioral functioning. One central question to rehabilitation research is whether the nature …
behavioral functioning. One central question to rehabilitation research is whether the nature …
Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain
Axonal injury is a major contributor to the clinical symptomatology in patients with traumatic
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …
From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury
The relationship between biomechanical forces and neuropathology is key to understanding
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …
Aberrant ER stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI
Persistent endoplasmic reticulum (ER) stress in neurons is associated with activation of
inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); …
inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); …
Volumetric MRI findings in mild traumatic brain injury (mTBI) and neuropsychological outcome
ED Bigler - Neuropsychology Review, 2023 - Springer
Region of interest (ROI) volumetric assessment has become a standard technique in
quantitative neuroimaging. ROI volume is thought to represent a coarse proxy for making …
quantitative neuroimaging. ROI volume is thought to represent a coarse proxy for making …
Radiological–pathological correlation of diffusion tensor and magnetization transfer imaging in a closed head traumatic brain injury model
TW Tu, RA Williams, JD Lescher, N Jikaria… - Annals of …, 2016 - Wiley Online Library
Objective Metrics of diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI)
can detect diffuse axonal injury in traumatic brain injury (TBI). The relationship between the …
can detect diffuse axonal injury in traumatic brain injury (TBI). The relationship between the …
Bi-directional changes in fractional anisotropy after experiment TBI: Disorganization and reorganization?
The current dogma to explain the extent of injury-related changes following rodent controlled
cortical impact (CCI) injury is a focal injury with limited axonal pathology. However, there is …
cortical impact (CCI) injury is a focal injury with limited axonal pathology. However, there is …
Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury
Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under
the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue …
the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue …
Spatiotemporal changes in blood-brain barrier permeability, cerebral blood flow, T2 and diffusion following mild traumatic brain injury
The blood-brain barrier (BBB) can be impaired following traumatic brain injury (TBI),
however the spatiotemporal dynamics of BBB leakage remain incompletely understood. In …
however the spatiotemporal dynamics of BBB leakage remain incompletely understood. In …