There is a good deal of interest in the development of monoclonal antibodies which may be
linked to drugs, toxins, or radioisotopes as targeting agents in the diagnosis and therapy of …

Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for
targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies …

The initial draining lymph node (Sentinel node) of a tumour may reflect the status of the
tumours spread to the remaining lymphatic bed. The sentinel node, which has been reported …

Abstract Objectives/Hypothesis The goals of the research study were to develop an easily
mastered, accurate, minimally invasive technique of sentinel node radiolocalization with …

The initial draining lymph node (sentinel node) has been successfully localized using
intraoperative vital dye map** and reportedly is predictive of regional nodal metastases in …

Tumor-associated monoclonal antibodies were radiolabeled with 125I and 131I and given iv
in pairs to 19 patients 1–26 days prior to surgical excision of primary and metastatic breast …

We describe here the first in vivo targeting of tumors with a single-chain antigen-binding
protein. The molecule, which was constructed and expressed in Escherichia coli, is a novel …

To investigate the nlIn labeling of tumor-localizing monoclonal antibodies (MoAb), we have
synthesized the chelate l-(p-iso-thiocyanatobenzyl) diethylenetriaminepentaacetic acid (p …

Clinical utility of murine mAbs is limited because many elicit Abs to murine Ig constant and
variable regions in patients. An Ab humanized by the current procedure of grafting all the …

Abstract Treatment of human breast or colon carcinoma cells with recombinantly derived
human leukocyte (clone A) interferon (IFN-α A) increases the surface expression of specific …