Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

H Xu, S Li, YS Liu - Signal Transduction and Targeted Therapy, 2022‏ - nature.com
Aging-induced alternations of vasculature structures, phenotypes, and functions are key in
the occurrence and development of vascular aging-related diseases. Multiple molecular and …

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

W He, N Kapate, CW Shields IV, S Mitragotri - Advanced drug delivery …, 2020‏ - Elsevier
Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO2 Heterostructured …

Z Cao, G Yuan, L Zeng, L Bai, X Liu, M Wu, R Sun… - ACS …, 2022‏ - ACS Publications
Sonodynamic therapy (SDT) and photothermal therapy (PTT) are two effective strategies for
the treatment of atherosclerotic plaques. However, the low yield of reactive oxygen species …

Smart transformable nanoparticles for enhanced tumor theranostics

J Chen, Z Jiang, YS Zhang, J Ding, X Chen - Applied Physics Reviews, 2021‏ - pubs.aip.org
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …

Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy

X Hou, D Zhong, H Chen, Z Gu, Q Gong, X Ma… - Carbohydrate …, 2022‏ - Elsevier
Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy
has raised increasing interest in recent decades, and many nanomedicines are prepared to …

Recent advances in stimulus‐responsive nanocarriers for gene therapy

C Yu, L Li, P Hu, Y Yang, W Wei, X Deng… - Advanced …, 2021‏ - Wiley Online Library
Gene therapy provides a promising strategy for curing monogenetic disorders and complex
diseases. However, there are challenges associated with the use of viral delivery vectors …

Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer

MM Khan, N Filipczak, VP Torchilin - Journal of Controlled Release, 2021‏ - Elsevier
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …

Nanoengineered polymeric rna nanoparticles for controlled biodistribution and efficient targeted cancer therapy

T Kim, HS Han, K Yang, YM Kim, K Nam, KH Park… - ACS …, 2024‏ - ACS Publications
RNA nanotechnology, including rolling circle transcription (RCT), has gained increasing
interest as a fascinating siRNA delivery nanoplatform for biostable and tumor-targetable …

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

J Chen, X Zhang, R Millican, J Sherwood… - Advanced drug delivery …, 2021‏ - Elsevier
Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries,
leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is …

Cell-penetrating peptides (CPPs): An overview of applications for improving the potential of nanotherapeutics

K Desale, K Kuche, S Jain - Biomaterials Science, 2021‏ - pubs.rsc.org
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …