Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms
that can withstand extended periods of inanimation. Since this discovery, the properties of …

Amorphous solids are conventionally formed by supercooling liquids or by concentrating
noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical …

The aim of this paper is to investigate the physicochemical properties of binary amorphous
dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling. The …

The aim of this study is to explore hot melt extrusion (HME) as a solvent-free drug loading
technique for preparation of stable amorphous solid dispersions using mesoporous silica …

Studying the thermal history and relaxation of solid amorphous drug product matrices by
calorimetry is a well-known approach, particularly in the context of correlating the matrix …

Cryopreservation of biological materials is predominantly done using liquid nitrogen, and its
application involves high maintenance costs and the need for periodical refilling of liquid …

Ball milling is used, not only to reduce the particle size of pharmaceutical powders, but also
to induce changes in the physical properties of drugs. In this work we prepared three crystal …

Valsartan (VAL) is an antihypertensive drug marketed in an amorphous form. Amorphous
materials can have different physicochemical properties depending on preparation method …