The impacts of tobacco and nicotine on HIV-1 infection, inflammation, and the blood-brain barrier in the central nervous system

AM Keane, TH Swartz - Frontiers in Pharmacology, 2024 - frontiersin.org
Human immunodeficiency virus (HIV-1) remains a persistent global health crisis. Even while
successfully virologically suppressed, people with HIV (PWH) experience a higher risk for …

HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43

J Yang, Y Li, H Li, H Zhang, H Guo, X Zheng, XF Yu… - EMBO …, 2024 - embopress.org
Despite the efficacy of highly active antiretroviral therapy in controlling the incidence and
mortality of AIDS, effective interventions for HIV-1-induced neurological damage and …

Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation

A Blanco, RA Coronado, N Arun, K Ma, RD Dar… - Proceedings of the …, 2024 - pnas.org
HIV latency regulation in monocytes and macrophages can vary according to signals
directing differentiation, polarization, and function. To investigate these processes, we …

Neuro‐HIV—New insights into pathogenesis and emerging therapeutic targets

D Sviridov, M Bukrinsky - The FASEB Journal, 2023 - Wiley Online Library
HIV‐associated neurocognitive disorders (HAND) is a term describing a complex set of
cognitive impairments accompanying HIV infection. Successful antiretroviral therapy (ART) …

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

LR Olari, S Liu, F Arnold, J Kühlwein, M Gil Miró… - Nature …, 2025 - nature.com
HIV-associated neurocognitive disorders (HAND) and viral reservoirs in the brain remain a
significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and …

Crosstalk between gut microbiome and neuroinflammation in pathogenesis of HIV-associated neurocognitive disorder

X Chen, J Wei, Y Zhang, Y Zhang, T Zhang - Journal of the Neurological …, 2024 - Elsevier
HIV-associated neurocognitive disorder (HAND) has become a chronic neurodegenerative
disease affecting the quality of life in people living with HIV (PLWH). Despite an established …

3D human tissue models and microphysiological systems for HIV and related comorbidities

DE Yin, AC Palin, TB Lombo, RN Mahon, B Poon… - Trends in …, 2024 - cell.com
Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …

Adult Human Brain Tissue Cultures to Study NeuroHIV

R Van Duyne, E Irollo, A Lin, JA Johnson, AM Guillem… - Cells, 2024 - mdpi.com
HIV-associated neurocognitive disorders (HAND) persist under antiretroviral therapy as a
complex pathology that has been difficult to study in cellular and animal models. Therefore …

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice

L Zhou, S Godse, N Sinha, S Kodidela, U Singh… - Pharmaceutics, 2024 - mdpi.com
Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from
neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on …