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The relationship between HIV‐1 neuroinflammation, neurocognitive impairment and encephalitis pathology: A systematic review of studies investigating post‐mortem …
The activities of HIV‐1 in the central nervous system (CNS) are responsible for a
dysregulated neuroinflammatory response and the subsequent development of HIV …
dysregulated neuroinflammatory response and the subsequent development of HIV …
The impacts of tobacco and nicotine on HIV-1 infection, inflammation, and the blood-brain barrier in the central nervous system
AM Keane, TH Swartz - Frontiers in Pharmacology, 2024 - frontiersin.org
Human immunodeficiency virus (HIV-1) remains a persistent global health crisis. Even while
successfully virologically suppressed, people with HIV (PWH) experience a higher risk for …
successfully virologically suppressed, people with HIV (PWH) experience a higher risk for …
HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43
J Yang, Y Li, H Li, H Zhang, H Guo, X Zheng, XF Yu… - EMBO …, 2024 - embopress.org
Despite the efficacy of highly active antiretroviral therapy in controlling the incidence and
mortality of AIDS, effective interventions for HIV-1-induced neurological damage and …
mortality of AIDS, effective interventions for HIV-1-induced neurological damage and …
Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation
HIV latency regulation in monocytes and macrophages can vary according to signals
directing differentiation, polarization, and function. To investigate these processes, we …
directing differentiation, polarization, and function. To investigate these processes, we …
Neuro‐HIV—New insights into pathogenesis and emerging therapeutic targets
HIV‐associated neurocognitive disorders (HAND) is a term describing a complex set of
cognitive impairments accompanying HIV infection. Successful antiretroviral therapy (ART) …
cognitive impairments accompanying HIV infection. Successful antiretroviral therapy (ART) …
α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia
LR Olari, S Liu, F Arnold, J Kühlwein, M Gil Miró… - Nature …, 2025 - nature.com
HIV-associated neurocognitive disorders (HAND) and viral reservoirs in the brain remain a
significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and …
significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and …
Crosstalk between gut microbiome and neuroinflammation in pathogenesis of HIV-associated neurocognitive disorder
X Chen, J Wei, Y Zhang, Y Zhang, T Zhang - Journal of the Neurological …, 2024 - Elsevier
HIV-associated neurocognitive disorder (HAND) has become a chronic neurodegenerative
disease affecting the quality of life in people living with HIV (PLWH). Despite an established …
disease affecting the quality of life in people living with HIV (PLWH). Despite an established …
3D human tissue models and microphysiological systems for HIV and related comorbidities
DE Yin, AC Palin, TB Lombo, RN Mahon, B Poon… - Trends in …, 2024 - cell.com
Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …
Adult Human Brain Tissue Cultures to Study NeuroHIV
R Van Duyne, E Irollo, A Lin, JA Johnson, AM Guillem… - Cells, 2024 - mdpi.com
HIV-associated neurocognitive disorders (HAND) persist under antiretroviral therapy as a
complex pathology that has been difficult to study in cellular and animal models. Therefore …
complex pathology that has been difficult to study in cellular and animal models. Therefore …
Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice
Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from
neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on …
neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on …